Clinical research has linked long-term Depo-Provera use to meningioma brain tumors. Thousands of women across the United States are now pursuing legal action against Pfizer. If you or a loved one was affected, you may have a case.
Cases filed nationally
against Pfizer
“Women who used Depo-Provera for five or more years were found to have a meningioma risk more than five times higher than non-users.”
Depo-Provera is a brand name for medroxyprogesterone acetate (DMPA), a hormonal contraceptive administered as an injection every three months. Manufactured by Pfizer (formerly Pharmacia & Upjohn), it has been prescribed to millions of women in the United States since receiving FDA approval in 1992.
For decades, Depo-Provera was considered a safe, convenient long-term birth control option — particularly for women who could not tolerate estrogen-based contraceptives. It works by releasing synthetic progestin that suppresses ovulation.
However, emerging research — including a landmark 2024 study published in the British Medical Journal — established a significant statistical link between prolonged Depo-Provera use and the development of meningioma: a brain tumor that grows on the membranes surrounding the brain and spinal cord. While often classified as benign, meningiomas can cause severe neurological damage and frequently require surgery.
Women who used Depo-Provera for five or more years were found to have a meningioma risk more than five times higher than non-users. Many required brain surgery and experienced life-altering symptoms — including vision loss, headaches, cognitive decline, and loss of motor function.
Important: Pfizer has faced allegations that it failed to adequately warn patients and healthcare providers of this risk, despite access to data suggesting the connection. If you used Depo-Provera and were later diagnosed with a meningioma, you may be entitled to significant financial compensation.
Legal action is underway across the United States. Here is what led to this litigation and what victims are seeking.
Peer-reviewed research — including a major 2024 BMJ study of over 18,000 women — established a statistically significant association between long-term Depo-Provera use and intracranial meningioma. Women using it for five-plus years faced more than five times the typical risk.
Thousands of women who developed meningiomas have filed lawsuits against Pfizer, alleging the company knew — or should have known — about this risk, yet failed to provide adequate warnings to patients and physicians. Cases are consolidating into multidistrict litigation (MDL) in federal court.
Plaintiffs are seeking compensation for medical expenses (including brain surgery and rehabilitation), lost wages, pain and suffering, and diminished quality of life. Settlements in similar mass tort cases have ranged from tens of thousands to millions of dollars per claimant.
You may have grounds for a lawsuit if you meet one or more of the following criteria. Many women qualify without realizing it — a free review costs you nothing.
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Your initial case evaluation is completely free with no strings attached. We review your situation, explain your legal options, and answer every question — with no fees unless we win your case.
Our attorneys specialize in pharmaceutical mass tort litigation. We understand the science behind the Depo-Provera cases and what it takes to hold powerful corporations accountable in court.
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